Give Us Your Tired &Weary… AND WE’LL GIVE THEM ACETYL L-CARNITINE
So, what is acetyl L-carnitine and why is it so important to anybody who is feeling fatigued? Here’s what we know. The amino acid L-carnitine is well known for its key role in the burning of fats. Specifically, L-carnitine transports fatty acids to the innermost section of the mitochondria (the cellular power plants for energy) where they are used to create adenosine triphosphate (ATP), the energy currency of the body. Studies have shown that carnitine deficiency lowers ATP levels in various tissues. Carnitine deficiency also increases the susceptibility to fatigue from, and decreases the rate of recovery following, strenuous physical activity.
Acetyl L-carnitine (ACL) is the acetyl ester of the amino acid L-carnitine, which transports fats into the mitochondria. In the mitochondria these fats are converted to an energy source. A nutrient and naturally occurring metabolite that is involved in lipid, carbohydrate and protein metabolism, ALC is naturally present in the human and animal body. The heart, brain, muscles, and testicles contain considerable concentrations of ALC, but its levels are dramatically reduced as we age.
An ALC/L-carnitine deficiency also increases the body’s susceptibility to fatigue and injury following strenuous physical activity. For these reasons, supplementing with L-carnitine has long been a favorite in weight-training circles, but as MRM has learned, ALC surpasses the metabolic potency and bioavailability of traditional L-carnitine to offer a range of holistic health advantages.
Acetyl L-Carnitine vs. L-Carnitine
Because it possesses its own acetyl acid group, ALC facilitates energetic pathways that L-carnitine supplementation alone cannot supply. The acetyls from ALC can combine with coenzyme A (the metabolized form of the vitamin pantothenic acid, which is responsible for metabolizing fatty acids) to create acetylcoenzyme A (A-CoA). This molecule plays a vital role in the citric acid cycle (the biological reactions within mitochondria that provide cellular energy). ALC can also give its acetyl group to choline to form the neurotransmitter acetylcholine. When cellular energy charges and A-CoA stores grow low, ALC supplementation replenishes both. And when cellular energy charges are high, L-carnitine can convert back to ALC to conserve the acetyl until it is needed for future energy generation.
How ALC Supports Metabolism
A 1993 Russian study observed that ALC administration for 10 days significantly increased maximum running speed and endurance. This tracks with a 2004 test that saw 59 percent of 30 patients suffering from fatigue report sizable improvements in their mental and bodily energy after ingesting ALC daily for 24 weeks. A 1997 study found that those runners taking 2 g of L-carnitine daily increased their top running speed by as much as 5.7 percent. While both L-carnitine and ALC are established providers of athletic performance boosts, as an esterified compound, ALC possesses impressive bioavailability to traverse cell walls and the bloodbrain barrier into the central nervous system. Indeed, a 2004 study appearing in the Annals of the New York Academy of Sciences compared ALC to L-carnitine’s effects, finding that while “ALC and L-carnitine were similar in increasing ambulatory activity in old rats and elevating carnitine levels in blood and brain…ALC was effective… in decreasing oxidative damage.” And, unlike the other ALC products on the market, MRM’s patented ALC formula maximizes this already potent bioavailability by virtue of being the first available via a liquid delivery system. The combination of enhanced bioavailability and ALC’s natural antioxidant capabilities demonstrates ALC’s versatility in supporting exercise and in supporting healthy stress levels and brain health.
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